///Platelet-rich plasma supplementation in arthroscopic repair of full-thickness rotator cuff tears: a randomized clinical trial.

Platelet-rich plasma supplementation in arthroscopic repair of full-thickness rotator cuff tears: a randomized clinical trial.

Date: December, 2016



Results on the effectiveness of PRP supplementation in arthroscopic rotator cuff repair are conflicting, making it difficult to draw definitive conclusions.


This was a prospective, randomized, and double-blind study with two groups of 20 patients each (PRP group and control group). Degenerative supraspinatus full-thickness tears grade C2-C3 were subjected to arthroscopic repair; PRP supplementation was given to patients in the PRP group. The outcomes were assessed by DASH, Constant scales, and ultrasound before and 6 months after surgery. Pain measured by VAS was evaluated preoperatively and 7 and 30 days after surgery.


The two groups did not differ significantly by age, sex, and dominance of the affected side. In all surgical procedures, a long head of the biceps tenotomy and single-row repair were performed. The preoperative VAS was 5.6 ± 2.4 in PRP group and 6.4 ± 1.5 in the control group (p > 0.05). The group supplemented with PRP reported a VAS significantly better in the first week (2.5 ± 1.9 vs 5.3 ± 2.1, p < 0.05) and during the first month after surgery (1.5 ± 1.0 vs 3.2 ± 1.7, p < 0.05) compared to the control group. The preoperative Constant and DASH scores were 39.95 ± 12 and 51 ± 15.2, respectively, in the PRP group and 41 ± 11 (p > 0.05) and 45 ± 12.6 (p > 0.05) in the control group. The average Constant score improved significantly after 6 months to 81 ± 11.2 (p < 0.05) in the PRP group and 78.5 ± 9 (p < 0.05) in the control group. No differences were noted between the two groups (p > 0.05). The DASH score after 6 months was 17.4 ± 8 (p < 0.05) for the treatment group (the PRP group) and 21 ± 8.4 (p < 0.05) for the control group. No statistically significant differences were found as regards the DASH score in the two groups after 6 months (p > 0.05). The two groups showed no differences in the ultrasound evaluation after 6 months either. No re-ruptures occurred in either group.


PRP leads to a reduction in pain during a short-term follow-up. Pain reduction allows for a more rapid recovery of mobilization and improvement in functionality.


Randomized controlled trial, Level of evidence, 1.



PRP means Platelet Rich Plasma. The Plasma liquid in the blood includes red and white blood cells and platelets. Platelets form 10% of the plasma and in the concept of PRP, the platelet ratio is flipped to 90%. It is given in the form of an injection to patients looking to treat tissue damages, skin issues etc.
A non-surgical therapy in nature, PRP is used for healing in several medicine fields including sports medicines and orthopedics. PRP is nothing but the patient’s own blood which is administered in a way such that the healing components (growth factors) present in the platelets are released, thus fuelling fast recovery.
PRP is majorly useful in cases of soft tissue injuries, including ligament sprains, muscle pulls / tears, tendon tears, tendonitis and tendinosis. It has been an effective way to treat cartilage degeneration like arthritis as well.
With its methodology, PRP is developed to heal the injured region through the initiation of growth factors in your platelets. It is a cure and not just a temporary solution to limit any injury.
In most cases, the procedure can be well tolerated by patients but there may be soreness after the injection as PRP induces


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